Sunday, November 22, 2009

How does OBAGI work? Hydroquinone mechanisms of action and info about tretinoin.

In this post, I'm just going to address the hydroquinone mechanisms of action:

Topical application of hydroquinone produces a reversible
depigmentation of the skin by inhibition of the enzymatic oxidation
of tyrosine to 3, 4-dihydroxyphenylalanine (dopa) and suppression
of other melanocyte metabolic processes.

There's also Tretinoin in the complete OBAGI system.

Below is copied from a response Dr. Wu had written in a question posed on RealSelf.com

Just a little more about Retin-A:
Retin-A / Tretinoin provides a light form of chemical peel that exfoliates the skin, enhances collage production (minimizes wrinkles), and evens skin tone (a treatment for hyperpigmentation).

Retin-A is the brand name for Tretinoin and is a topical prescription medication. Retin A can make your skin more sensitive to the sun; thus sunscreen/sunblocks are highly recommended adjuncts. Avoide sunlamps and tanning beds. We recommend avoiding areas of wounds, eczema, and muscosal areas such as the eyes, mouth, and nose. We also have our patients use tretinoin at night instead of in the morning because of the increased sun sensitivity during the day. When we start a patient on tretinoin, we usually have them start every other night for the first 2 weeks then increase to every night. We would like to personally monitor a patient's progress with this medication. We carry a skincare line in our office - Obagi - which utilizes tretinoin.

Our most common dosages of tretinoin that we prescribe in our Modesto, California office is 0.1% or 0.05%. Tretinoin is also available as a 0.025% strength.

Retin-A/Tretinoin works by thinning the outermost layer of the skin - the stratum corneum, while cells in the epidermis are stimulated to produce a thicker epidermis layer. Collagen production and cellular growth in the dermis layer also increases. These changes are fully appreciated after about 2 months of continued use. At that time one would see improvement with acne, hyperpigmentation, pore size, and texture. Continued daily use is recommended to keep these improvements, and some skin care specialists recommend a modified maintenance route with Retin-A/Tretinoin.

Retin-A has been used to treat acne and for skin rejuvenation purposes. It is not known whether Retin-A is harmful to an unborn baby or nursing baby. Talk to your doctor in person about using Retin-A, especially if you are pregnant or just delivered your baby.



Note: This posting and website is not intended to create a physician patient relationship. Please see your physician in person. This disclaimer applies to our other websites as well – feel free to visit: Plastic Surgery Modesto, Modesto Plastic Surgery, Modesto Plastic Surgeon, Surgical Artistry Modesto Vein Center, Acupuncture in Modesto, Plastic Surgery Stockton, Calvin Lee, Cosmetic Surgery Modesto.

45 comments:

  1. I am wondering if you did start using Obagi and what you think of it? It was suggested that I use it, but I am not sure if it is worth the price. Why not just use retin-a and hydroquinone on their own?

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  2. Hi: I am relatively new to Obagi but thought I'd pass along my results and history. I am 55 and had a lot of sun damage and pigmentation. When I was young, I had freckles - they grew all these years til they took over! My wrinkles were getting bad as well. So last April, I tried Fraxel. I reacted badly - looked like an oriental tomato for a long time and had AWFUL breakouts for several months. After 3 months, skin looked some better but had a ways to go. I was religious with sunblock and hats. Then, 6 months later when I went for pictures, ALL the pigmentation was back. I was frustrated. I'd spent lots of money for the Fraxel and had no good result. I decided ot to continue the Fraxel treatments. Then my skin care person who did the Fraxel, recommended I just try Clear to start. She gave me some samples in little jars. Wow! In 4 weeks, it almost all disappeared! I continued and lost most of the awful brown spots on my face. Then I wanted to address the pores and wrinkles. So we added the 'blender and tretinoin' and I started it a couple of weeks ago, lightly, every other night. So far so good.

    At the same time I decided it was time to attack the redness and blotchiness (melasma) on my neck and chest area so started the Obagi Decollette system a week ago.

    No, it's not cheap but so far it's way cheaper than the Fraxel. And I still use a major sun block every day, even when I do not go outdoors. I live in S. FL so the sun is never far away. I'm using Sheisedo for the face for my sunblock - 36 for most every day and 55 when I know I'll be out longer (like on our boat or on a golf cart) and always wear hats (I HATE HATS).

    I'm assuming I'm about 6 months away from going to maintenance on any of this but I have had several people tell me I already look 10 yrs younger. I'm not sure that's right but hey, I'll take those compliments.

    OH, and on top of this, I am also on the Wiley face cream which essentially is applied every other night and every other morning.

    Anyone using the Wiley with the Obagi out there?

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  4. 好的開始並不代表會成功,壞的開始並不代表是失敗...............................................................

    ReplyDelete
  5. 死亡是悲哀的,但活得不快樂更悲哀。.................................................................                           

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    ReplyDelete
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  8. 在莫非定律中有項笨蛋定律:「一個組織中的笨蛋,恆大於等於三分之二。」. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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  9. 與人相處不妨多用眼睛說話,多用嘴巴思考. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

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  10. That was really an informative blog! I surely try Obagi product and let me see how it really works on me.

    obagi Philippines

    ReplyDelete
  11. External program of hydroquinone is a reversible
    depigmentation of the epidermis by self-consciousness of the enzymatic oxidation of tyrosine to 3, 4-dihydroxyphenylalanine (dopa) and suppression of other melanocyte metabolic procedures.


    Obagi

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  12. Thanks for your valuable tip on obagi. Any one know that obagi is best for all type skin. But your description is pointed out more and more information about obagi.

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  13. Your blog is very nice. Creation of blog is really good. I am a big fan of Obagi Products. Thank you for giving me more information about obagi. No doubt obagi is a Best skin care product.

    ReplyDelete